Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane
Identifieur interne : 001054 ( Main/Exploration ); précédent : 001053; suivant : 001055Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane
Auteurs : Rosanna La Rocca [Italie] ; Rossana Tallerico [Italie] ; Almosawy Talib Hassan [Italie, Iraq] ; Gobind Das [Italie] ; Lakshmikanth Tadepally [Suède] ; Marco Matteucci [Danemark] ; Carlo Liberale [Italie] ; Maria Mesuraca [Italie] ; Domenica Scumaci [Italie] ; Francesco Gentile [Italie] ; Gheorghe Cojoc [Italie] ; Gerardo Perozziello [Italie] ; Antonio Ammendolia [Italie] ; Adriana Gallo [Italie] ; Klas K Rre [Suède] ; Giovanni Cuda [Italie] ; Patrizio Candeloro [Italie] ; Enzo Di Fabrizio [Italie] ; Ennio Carbone [Italie, Suède]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
In our body, cells are continuously exposed to physical forces that can regulate different cell functions such as cell proliferation, differentiation and death. In this work, we employed two different strategies to mechanically stress cancer cells. The cancer and healthy cell populations were treated either with mechanical stress delivered by a micropump (fabricated by deep X-ray nanolithography) or by ultrasound wave stimuli. A specific down-regulation of Major Histocompatibility Complex (MHC) class I molecules expression on cancer cell membrane compared to different kinds of healthy cells (fibroblasts, macrophages, dendritic and lymphocyte cells) was observed, stimulating the cells with forces in the range of nano-newton, and pressures between 1 and 10 bar (1 bar = 100.000 Pascal), depending on the devices used. Moreover, Raman spectroscopy analysis, after mechanical treatment, in the range between 700–1800 cm−1, indicated a relative concentration variation of MHC class I. PCA analysis was also performed to distinguish control and stressed cells within different cell lines. These mechanical induced phenotypic changes increase the tumor immunogenicity, as revealed by the related increased susceptibility to Natural Killer (NK) cells cytotoxic recognition.
Url:
DOI: 10.1371/journal.pone.0111758
PubMed: 25541692
PubMed Central: 4277281
Affiliations:
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xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Ammendolia, Antonio" sort="Ammendolia, Antonio" uniqKey="Ammendolia A" first="Antonio" last="Ammendolia">Antonio Ammendolia</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Surgical and Medical Sciences, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical and Medical Sciences, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Gallo, Adriana" sort="Gallo, Adriana" uniqKey="Gallo A" first="Adriana" last="Gallo">Adriana Gallo</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Endocrinology and Experimental Oncology Institute, CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Endocrinology and Experimental Oncology Institute, CNR, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="K Rre, Klas" sort="K Rre, Klas" uniqKey="K Rre K" first="Klas" last="K Rre">Klas K Rre</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Cuda, Giovanni" sort="Cuda, Giovanni" uniqKey="Cuda G" first="Giovanni" last="Cuda">Giovanni Cuda</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Candeloro, Patrizio" sort="Candeloro, Patrizio" uniqKey="Candeloro P" first="Patrizio" last="Candeloro">Patrizio Candeloro</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Di Fabrizio, Enzo" sort="Di Fabrizio, Enzo" uniqKey="Di Fabrizio E" first="Enzo" last="Di Fabrizio">Enzo Di Fabrizio</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff4"><addr-line>King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia</addr-line></nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Carbone, Ennio" sort="Carbone, Ennio" uniqKey="Carbone E" first="Ennio" last="Carbone">Ennio Carbone</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25541692</idno><idno type="pmc">4277281</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277281</idno><idno type="RBID">PMC:4277281</idno><idno 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Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Italian Institute of Technology (IIT), Genova, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Italian Institute of Technology (IIT), Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Tallerico, Rossana" sort="Tallerico, Rossana" uniqKey="Tallerico R" first="Rossana" last="Tallerico">Rossana Tallerico</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Talib Hassan, Almosawy" sort="Talib Hassan, Almosawy" uniqKey="Talib Hassan A" first="Almosawy" last="Talib Hassan">Almosawy Talib Hassan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Microbiology, College of Medicine, University of Thi-Qar, Nasseriah, Iraq</addr-line></nlm:aff><country xml:lang="fr">Iraq</country><wicri:regionArea>Department of Microbiology, College of Medicine, University of Thi-Qar, Nasseriah</wicri:regionArea><wicri:noRegion>Nasseriah</wicri:noRegion></affiliation></author><author><name sortKey="Das, Gobind" sort="Das, Gobind" uniqKey="Das G" first="Gobind" last="Das">Gobind Das</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff4"><addr-line>King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia</addr-line></nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Tadepally, Lakshmikanth" sort="Tadepally, Lakshmikanth" uniqKey="Tadepally L" first="Lakshmikanth" last="Tadepally">Lakshmikanth Tadepally</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Science for Life Laboratory, Department of Medicine, Karolinska Institute, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Science for Life Laboratory, Department of Medicine, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Matteucci, Marco" sort="Matteucci, Marco" uniqKey="Matteucci M" first="Marco" last="Matteucci">Marco Matteucci</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Nanotech Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Nanotech Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby</wicri:regionArea><wicri:noRegion>Kongens Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Liberale, Carlo" sort="Liberale, Carlo" uniqKey="Liberale C" first="Carlo" last="Liberale">Carlo Liberale</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff4"><addr-line>King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia</addr-line></nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Mesuraca, Maria" sort="Mesuraca, Maria" uniqKey="Mesuraca M" first="Maria" last="Mesuraca">Maria Mesuraca</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Scumaci, Domenica" sort="Scumaci, Domenica" uniqKey="Scumaci D" first="Domenica" last="Scumaci">Domenica Scumaci</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Gentile, Francesco" sort="Gentile, Francesco" uniqKey="Gentile F" first="Francesco" last="Gentile">Francesco Gentile</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Cojoc, Gheorghe" sort="Cojoc, Gheorghe" uniqKey="Cojoc G" first="Gheorghe" last="Cojoc">Gheorghe Cojoc</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Perozziello, Gerardo" sort="Perozziello, Gerardo" uniqKey="Perozziello G" first="Gerardo" last="Perozziello">Gerardo Perozziello</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Ammendolia, Antonio" sort="Ammendolia, Antonio" uniqKey="Ammendolia A" first="Antonio" last="Ammendolia">Antonio Ammendolia</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Surgical and Medical Sciences, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical and Medical Sciences, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Gallo, Adriana" sort="Gallo, Adriana" uniqKey="Gallo A" first="Adriana" last="Gallo">Adriana Gallo</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Endocrinology and Experimental Oncology Institute, CNR, Napoli, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Endocrinology and Experimental Oncology Institute, CNR, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="K Rre, Klas" sort="K Rre, Klas" uniqKey="K Rre K" first="Klas" last="K Rre">Klas K Rre</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Cuda, Giovanni" sort="Cuda, Giovanni" uniqKey="Cuda G" first="Giovanni" last="Cuda">Giovanni Cuda</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Candeloro, Patrizio" sort="Candeloro, Patrizio" uniqKey="Candeloro P" first="Patrizio" last="Candeloro">Patrizio Candeloro</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Di Fabrizio, Enzo" sort="Di Fabrizio, Enzo" uniqKey="Di Fabrizio E" first="Enzo" last="Di Fabrizio">Enzo Di Fabrizio</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff4"><addr-line>King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia</addr-line></nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Carbone, Ennio" sort="Carbone, Ennio" uniqKey="Carbone E" first="Ennio" last="Carbone">Ennio Carbone</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, University of “Magna Graecia”, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In our body, cells are continuously exposed to physical forces that can regulate different cell functions such as cell proliferation, differentiation and death. In this work, we employed two different strategies to mechanically stress cancer cells. The cancer and healthy cell populations were treated either with mechanical stress delivered by a micropump (fabricated by deep X-ray nanolithography) or by ultrasound wave stimuli. A specific down-regulation of Major Histocompatibility Complex (MHC) class I molecules expression on cancer cell membrane compared to different kinds of healthy cells (fibroblasts, macrophages, dendritic and lymphocyte cells) was observed, stimulating the cells with forces in the range of nano-newton, and pressures between 1 and 10 bar (1 bar = 100.000 Pascal), depending on the devices used. Moreover, Raman spectroscopy analysis, after mechanical treatment, in the range between 700–1800 cm<sup>−1</sup>, indicated a relative concentration variation of MHC class I. PCA analysis was also performed to distinguish control and stressed cells within different cell lines. 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Whiteman</name></author><author><name sortKey="Reeves, Mm" uniqKey="Reeves M">MM Reeves</name></author><author><name sortKey="Paratz, Jd" uniqKey="Paratz J">JD Paratz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bussani, R" uniqKey="Bussani R">R Bussani</name></author><author><name sortKey="De Giorgio, F" uniqKey="De Giorgio F">F De-Giorgio</name></author><author><name sortKey="Abbate, A" uniqKey="Abbate A">A Abbate</name></author><author><name sortKey="Silvestri, F" uniqKey="Silvestri F">F Silvestri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynen, K" uniqKey="Reynen K">K Reynen</name></author><author><name sortKey="Kockeritz, U" uniqKey="Kockeritz U">U Köckeritz</name></author><author><name sortKey="Strasser, Rh" uniqKey="Strasser R">RH Strasser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Autier, P" uniqKey="Autier P">P Autier</name></author><author><name sortKey="Boniol, M" uniqKey="Boniol M">M Boniol</name></author><author><name sortKey="Heanue, M" uniqKey="Heanue M">M Heanue</name></author><author><name sortKey="Colombet, M" uniqKey="Colombet M">M Colombet</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Danemark</li><li>Iraq</li><li>Italie</li><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="La Rocca, Rosanna" sort="La Rocca, Rosanna" uniqKey="La Rocca R" first="Rosanna" last="La Rocca">Rosanna La Rocca</name></noRegion><name sortKey="Ammendolia, Antonio" sort="Ammendolia, Antonio" uniqKey="Ammendolia A" first="Antonio" last="Ammendolia">Antonio Ammendolia</name><name sortKey="Candeloro, Patrizio" sort="Candeloro, Patrizio" uniqKey="Candeloro P" first="Patrizio" last="Candeloro">Patrizio Candeloro</name><name sortKey="Carbone, Ennio" sort="Carbone, Ennio" uniqKey="Carbone E" first="Ennio" last="Carbone">Ennio Carbone</name><name sortKey="Cojoc, Gheorghe" sort="Cojoc, Gheorghe" uniqKey="Cojoc G" first="Gheorghe" last="Cojoc">Gheorghe Cojoc</name><name sortKey="Cuda, Giovanni" sort="Cuda, Giovanni" uniqKey="Cuda G" first="Giovanni" last="Cuda">Giovanni Cuda</name><name sortKey="Das, Gobind" sort="Das, Gobind" uniqKey="Das G" first="Gobind" last="Das">Gobind Das</name><name sortKey="Di Fabrizio, Enzo" sort="Di Fabrizio, Enzo" uniqKey="Di Fabrizio E" first="Enzo" last="Di Fabrizio">Enzo Di Fabrizio</name><name sortKey="Gallo, Adriana" sort="Gallo, Adriana" uniqKey="Gallo A" first="Adriana" last="Gallo">Adriana Gallo</name><name sortKey="Gentile, Francesco" sort="Gentile, Francesco" uniqKey="Gentile F" first="Francesco" last="Gentile">Francesco Gentile</name><name sortKey="La Rocca, Rosanna" sort="La Rocca, Rosanna" uniqKey="La Rocca R" first="Rosanna" last="La Rocca">Rosanna La Rocca</name><name sortKey="Liberale, Carlo" sort="Liberale, Carlo" uniqKey="Liberale C" first="Carlo" last="Liberale">Carlo Liberale</name><name sortKey="Mesuraca, Maria" sort="Mesuraca, Maria" uniqKey="Mesuraca M" first="Maria" last="Mesuraca">Maria Mesuraca</name><name sortKey="Perozziello, Gerardo" sort="Perozziello, Gerardo" uniqKey="Perozziello G" first="Gerardo" last="Perozziello">Gerardo Perozziello</name><name sortKey="Scumaci, Domenica" sort="Scumaci, Domenica" uniqKey="Scumaci D" first="Domenica" last="Scumaci">Domenica Scumaci</name><name sortKey="Talib Hassan, Almosawy" sort="Talib Hassan, Almosawy" uniqKey="Talib Hassan A" first="Almosawy" last="Talib Hassan">Almosawy Talib Hassan</name><name sortKey="Tallerico, Rossana" sort="Tallerico, Rossana" uniqKey="Tallerico R" first="Rossana" last="Tallerico">Rossana Tallerico</name></country><country name="Iraq"><noRegion><name sortKey="Talib Hassan, Almosawy" sort="Talib Hassan, Almosawy" uniqKey="Talib Hassan A" first="Almosawy" last="Talib Hassan">Almosawy Talib Hassan</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Tadepally, Lakshmikanth" sort="Tadepally, Lakshmikanth" uniqKey="Tadepally L" first="Lakshmikanth" last="Tadepally">Lakshmikanth Tadepally</name></region><name sortKey="Carbone, Ennio" sort="Carbone, Ennio" uniqKey="Carbone E" first="Ennio" last="Carbone">Ennio Carbone</name><name sortKey="K Rre, Klas" sort="K Rre, Klas" uniqKey="K Rre K" first="Klas" last="K Rre">Klas K Rre</name></country><country name="Danemark"><noRegion><name sortKey="Matteucci, Marco" sort="Matteucci, Marco" uniqKey="Matteucci M" first="Marco" last="Matteucci">Marco Matteucci</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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